The earliest evidence of the medicinal use of cannabis comes from a herbalist written five thousand years ago under the Chinese emperor Shennun. Cannabis has been recommended as a remedy for malaria, constipation, rheumatic pains, "absent-mindedness" and "women's problems", as an analgesic for surgery and childbirth. This plant is widely used in Asia, the Middle East, southern Africa and South America. In India, cannabis was recommended for clarification of consciousness, as an antipyretic and hypnotic, as a medicine for dysentery, as a means of increasing appetite, improving digestion, relieving headaches and treating sexually transmitted diseases.
The first Western physician to take an interest in cannabis as a medicine was O'Shaughnessy, a young professor at the Medical College in Calcutta, who oversaw its use in India. In a work that was published in 1839, the professor wrote that tincture of hemp (an alcoholic solution for oral administration) has established itself as an effective pain reliever. The professor was also impressed by her ability to relax muscles, thanks to which he called cannabis "the most valuable anticonvulsant."
And in the 1854th century, cannabis became one of the most widely used medicines in Europe. In England, drugs based on it soon became "over the counter", and in XNUMX were included in the US Pharmacopoeia, after which the American market was flooded with drugs containing cannabis.
In 1990, researchers identified receptors in the brain that are stimulated by tetrohydrocannabinol (THC) and identified the gene responsible for their development. This discovery marked the beginning of the study of the endocannabinoid system of our body. In 1992, scientists identified a chemical present in the human body that affects these receptors. The substance was named anandamide (ananda in Sanskrit means "bliss").
Cannabidiol (CBD, CBD) is one of at least 113 cannabinoids found in cannabis. CBD is the main phytocannabinoid, and its share in plant extract can reach 40%. CBD does not have any of the psychoactive properties that tetrahydrocannabinol (THC) has. It is the content of tetrahydrocannabinol (THC) and its psychoactive (euphoric and considered a narcotic) effect that led to the ban on the use of hemp for treatment for the past 60 years.
Cannabidiol (CBD, CBD) does not cause an effect on the psyche, but has a very powerful analgesic, anti-cancer, anti-inflammatory and antiemetic effect. But as often happens - “they poured water out of the font, threw out the child as well” - the ban extended to the whole plant. It took many years for the scientific world to take a fresh look at this plant, this natural pharmacy, a storehouse of useful components and was able to remove psychoactive tetrahydrocannabinol from the plant, leaving only cannabidiols - this is how the medical form of cannabis appeared, the process of "rehabilitation" began. According to international agreements, the allowed THC content in medicinal cannabis preparations should be between 0,08% and 2% in Switzerland.
The human body contains cannabinoid receptors - CB1 and CB2. These receptors are located in almost all organs and tissues of the human body and are combined into a single endocannabinoid system of the body. CB1 receptors are located in nerve synapses in all organs, including the brain. Participate in the regulation of all functions of our body. They are responsible for the state of memory, feeling of hunger or satiety, a sense of pleasure, for motivation, a sense of time. The "second breath in athletes" opens against the background of an additional release of anandamide and stimulation of the CB1 receptor by it during increased physical activity. CB2 receptors are located in immune cells and are responsible for the immune response - regulating body temperature and inflammation. By connecting with the receptor, cannabinoids activate physiological processes in these organs and improve overall health.
CB1 and CB2 receptors have been found in the cell lines of malignant tumors such as astrocytoma, breast, prostate and lung cancer. Preclinical studies have shown that THC and CBD are able to prevent or slow down tumor growth, mainly due to the initiation of apoptosis. Stimulation of cannabinoid receptors can also prevent metastatic processes by inhibiting cell adhesion and migration, which has been demonstrated in breast, prostate, lung, and cervical cancer cell lines.
Here is a list of diseases in which cannabinoids have a positive effect according to many years of medical observations:
- Chronic pain syndrome of non-oncological and oncological origin, including neuropathic pain. Treatment of chronic pain associated with arthritis, osteoarthritis;
- Nausea and vomiting as a complication of chemotherapy;
- Anorexia of various origins. Stimulating appetite in HIV / AIDS and cancer;
- Antineoplastic action;
- Spasticity in multiple sclerosis;
- Epilepsy;
- Amyotrophic lateral sclerosis;
- Spinal cord injury and spinal cord diseases;
- Traumatic brain injury. Intracranial hemorrhage. Hemorrhagic stroke. Ischemic stroke;
- Mental and psychological disorders - anxiety disorders;
- Sleep disorders. CBD has shown different effects on sleep depending on the dose. In particular, low doses of CBD had a stimulatory effect, which is why low doses of CBD have been investigated for its potential use in excessive daytime sleepiness (EDS). Medium to high doses of CBD are sedating, so medium and high doses of CBD are being considered for potential use in sleep disorders, including insomnia;
- Depression - works similarly to antidepressants;
- Post-traumatic stress disorder;
- Possibility of addiction substitution therapy to overcome the abuse of legal and illegal narcotic and psychotropic drugs - a single administration of CBD compared with placebo attenuates the subjective induced craving for drugs, measured at 1 hour using a visual analogue scale and the decrease in cravings persisted even 7 days after use CBD;
- Alzheimer's disease and dementia - has a positive effect on a number of characteristic symptoms, such as night motor activity, behavioral and sleep disorders, agitation;
- Schizophrenia and psychosis;
- Movement disorders - receptors of the endocannabinoid system are densely represented in the basal ganglia, areas of the brain that control movement;
- Dystonia;
- Parkinson's disease - a significant improvement in symptoms such as tremors, rigidity, bradykinesia, as well as improved sleep and decreased pain intensity;
- Tourette's syndrome - a significant improvement in the condition of patients with oral administration;
- Diseases of the gastrointestinal tract, including irritable bowel syndrome, as well as inflammatory bowel diseases (Crohn's disease, ulcerative colitis);
- Diabetes. Diabetic neuropathy;
- Increased weight. Obesity.
In many countries of the world today, practicing doctors have permission to prescribe medicinal cannabis and cannabinoids for the symptomatic treatment of nausea and vomiting caused by cytostatics, chronic pain syndrome, spastic phenomena in multiple sclerosis and cachexia in AIDS patients. The use of such drugs can improve the quality of life of patients.
CANABIS AND EFFECTS OF CHEMOTHERAPY
The chemotherapy method, which has gained popularity over the past few decades, has become one of the most important treatments for cancer. The drugs that are injected intravenously every few weeks are perhaps the most potent and toxic chemical compounds in the entire arsenal of substances used in medicine. The most widely used drugs include Cisplatin, Doxorubicin, Cyclophosphamide, Ifosfamide, and others. Cisplatin can cause deafness or lead to severe renal impairment that threatens the patient's life. Ifosfamide can cause bleeding and bruising, while cyclophosphamide suppresses the immune system, and doxorubicin can damage the heart muscle. Almost all of the aforementioned drugs cause hair loss, and each of them, while suppressing the primary cancer, can lead to the development of another form of cancer. Doses must be carefully calculated to prevent renal, cardiac or respiratory failure.
However, the most common and, for most patients, the most unpleasant side effect of these drugs is very severe nausea and vomiting. As the results of various research programs show, cannabis can be a remarkably effective substitute for standard drugs for nausea and vomiting. In one study, in a group of 56 patients who were not helped by conventional antiemetic drugs, 78% of patients resolved all symptoms after taking cannabis.
AIDS and HIV
Cannabis is becoming an increasingly popular treatment for not only nausea, vomiting, and weight loss, but other AIDS symptoms as well. It took more than a decade for the general public to grasp the gravity of the HIV epidemic. Unfortunately, it may take another ten years for doctors to accept alternative treatments for this condition.
WAITING FOR THE LEGALIZATION OF MEDICAL CANNABIS
The ability of CBD to act on the endocannabinoid system and the neurotransmitter system in brain tissue has made it useful in the treatment of neurological disorders. Contrary to the cannabis misconception, cannabidiol is effective in protecting our brain and cognitive function. It is surprising that the use of alcohol and tobacco is legal, and the use of cannabis is prohibited in many countries around the world. Moreover, cannabis dramatically reduces dependence on smoking, alcoholism, drug addiction.
CBD is a safe and well-tolerated therapy for the treatment of symptoms of epilepsy, multiple sclerosis, Alzheimer's disease, schizophrenia and other bipolar disorders. Certain types of epilepsy occur due to disturbances in the endocannabinoid system, when there are not enough enzymes that destroy excess anandamide. As a result, a more or less frequent series of seizures exhausting a person. Taking cannabinoids stops the seizures almost immediately. CBD studies have shown promising results in the treatment of neuroses, depressive conditions, obsessive fears and, with constant feelings of anxiety, disturbances in the sleep formula, thereby contributing to an improvement in the quality of life of patients.
In the near future, cannabis will take its rightful place in the treatment of oncology, since its powerful capabilities have been discovered to stop the proliferation of tumor cells and promote their apoptosis (self-destruction). Cannabidiol also inhibits the metastasis of tumors throughout the body. It was found that it protects healthy cells and contributes to the normalization of their functions in conditions of severe intoxication and inflammation. Perhaps there is no stronger remedy that could eliminate the indomitable nausea and vomiting after a course of chemotherapy. Moreover, cannabis clearly improves appetite, and this is almost impossible against the background of severe intoxication.
CBD and other cannabinoids in cannabis, acting through the cannabinoid receptor system, help regulate (restore) physiological processes - improve appetite, sleep, mood, memory, and most importantly, eliminate pain. Cannabis blocks the transmission of pain impulses through the nerve synapse. It is the best remedy for migraines, menstrual cramps, chronic pain after trauma, including "phantom" pain.
Recent studies have shown the role of cannabis in the restoration of bone structure and integrity (involved in the restoration of collagen in the bone tissue and periosteum). So many positive effects with no side effects at all! There are no statistics on overdose, deaths and addiction. The US, EU, Canada, Israel, England, and dozens of other countries have approved CBD. There are thousands of patented methods of using CBD in medicine all over the world!
The latest survey showed that the population for the most part knows about the possibilities of medical cannabis and wants it to become available in difficult life situations on the recommendation of a doctor. Interesting information in conclusion. One cannabis drug company has a list of diseases and conditions for which cannabidiol (CBD) will have a positive effect on its website. This list contains 187 (!) Diseases, and this list is not yet complete. It is only natural that there is a total legalization of medical cannabis all over the world. This drug is the future.
The Kiev Center for Fungotherapy, Bioregulation and Ayurveda has the following medicinal cannabis CBD preparations:
CBD Oil 15% Pure Sport is intended for people who are professionally and actively involved in sports. It has a positive effect on the performance of the body during exercise, muscle regeneration and skin damage.
The ointment can be used during skin inflammations to regenerate the skin, soothe irritations and slow down the aging process of the skin. It is also effective for muscle pain, joint pain, varicose veins, and hemorrhoids. The ointment has antioxidant properties, protects against drying out of the skin, relieves irritation, prevents itching and protects skin cells from free radicals.
Doctors of the Kiev Center for Fungotherapy, Bioregulation and Ayurveda will consult you for free on
tel: (097) 231-74-44, (050) 331-74-44, (063) 187-78-78, +38 (098) 583-85-85 (Viber), +38 (093) 688- 25-88 (WhatsApp, Telegram)
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