in section Oncology
Angiogenesis - The formation of new blood vessels in an organ or tissue. In a healthy body processes angiogenesis proceed at a moderate intensity, and are activated only when the elimination of foci of inflammation, regeneration of damaged tissues, sewage clots, scarring and other recovery processes, as well as the growth and development of the organism. In the development of cancer and the formation of tumor microvessels forming one's own vasculature is an important step. Tumor at the location of its origin carries infiltration into the surrounding tissues, the further growth and spread throughout the body. Tumor It receives oxygen and nutrients by diffusion from the surrounding tissue.
Tumor foci may undergo involution and stay in this state indefinitely.
Go to the stage of the tumor progression is associated with the creation of its own vascular network, providing its needs as a result created the possibility of rapid increase in tumor malignancy and manifestations. At this stage - the formation and implementation of its own tumor angiogenesis manifests itself as a disease.
tumor angiogenesis
tumor angiogenesis is key in the development of malignant neoplasms. Foci of malignant growth are found in a large number of surveyed people with normal health without signs onkozabolevanija. Malignant cells were detected in more than a third of practically healthy women aged approximately 50 years, and the incidence of cancer in women of this age group is 1%. A similar pattern for prostate cancer, micro-foci of malignant degeneration is observed in many older men, who had no reason to go to an oncologist and died from other causes. At autopsy, single malignant cells in the thyroid gland are found in virtually all individuals aged 50-70 years (with a thyroid cancer frequency in this age group at the level of 0,1%).
Thus, it can be argued that the presence of cancer cells in the body has the character of biological laws, for a significant period of life of people can follow them and thus transformed into a cancer in only a small number of cases. One of the main factors that determine this transformation is tumor angiogenesis.
These facts make it possible to treat tumor angiogenesis as a separate pathophysiological phenomenon of tumors following the initial stages of tumor growth. In this regard, the development of oncology diseases stacked in two stages. The first, genetic instability, which manifests itself as a result of genetic predisposition, the effect of carcinogens or implementation of spontaneous mutations leading to malignant transformation of cells and the formation of microscopic tumors.
To display the properties of malignancy "sleeping" tumor needs further stimulus and its implementation. This process is determined by the development of tumor angiogenesis, and as a result, tumor progression and clinical manifestations of the disease.
The mechanism of the formation of new vessels is inherent in nature, it is necessary, in particular, in the process of pregnancy (for the formation of the placenta) of the ovulatory cycle and, to restore the integrity of the tissue during wound healing and erosion. The process is realized with the participation of factors (both stimulating and suppressing angiogenesis), produced by regenerating tissue, vascular endothelium and blood. In this process, a hemostatic system is involved, reacting to blood loss from the damaged vessel and activating the mechanisms of restoring tissue integrity. In conditions of realization of physiological functions (menstrual cycle) or in the process of repair of damaged tissue, both homeostatic systems - angiogenesis and hemostasis - function as a single whole.
The formation of new blood vessels is an important component of the process of chronic inflammation. Due to the similarity of neovascularization in chronic inflammation, the mechanism of tumor angiogenesis called nonhealing wounds.
However, tumor angiogenesis is fundamentally different from other conditions: the nature of the angiogenic stimulus; growth characteristics of vessels and their histological organization; the formation of self-sustaining mechanism for tumor progression. Angiogenesis is essential for developing a tumor, it is manifested by the action of hypoxic stress and chronic inflammation, changes in tissue pH, long compression fabric, the effect of other factors which activate the corresponding genes.
The intensity of angiogenesis growing tumors is characterized by a density of vessels, which is dictated by the tumor itself; immaturity of these vessels, which distinguishes them from the vessels, vascularized healthy tissue; and to form increased permeability "vascular holes" determining tissue edema, swelling of the tumor mass, the yield of tumor cells and mediators in tissue space. This increased metabolic demands of tumor progression as it is, and the rate of growth of its vessels in 50-100 times the growth of blood vessels of healthy tissue.
Ultimately, the development of angiogenesis leads to the formation of blood supply in the overall system isolated "vascular buds", consisting of a tumor and its vascular supply network providing the possibility of further growth. As this growth is the tumor gets its own structure. This structure includes parenchyma composed of tumor cells and their feeding vessels and stroma, comprising the elements of healthy tissue. This entire structure acts as a single unit, and the process of angiogenesis is dictated by the "interests" tumor - Providing it with oxygen, plastic and energy resources .. In the end, the development of angiogenesis leads to the formation of the common system of blood supply to the isolated "vascular kidney", consisting of a tumor and its vascular supply network, providing opportunities for further growth.
The rate of tumor growth is directly dependent on the intensity of the formation of microvessels. The rapid increase in density defines "hot spots" of tumor growth and can serve as a prognostic indicator for a number of tumors - aggressive growth rate and metastasis of blood vessels.
Approximately in 25% of women operated on for breast cancer with no metastases to regional lymph nodes, a relapse of the disease was observed. It is advisable to separate such patients into a separate risk group for ongoing monitoring. The density of microvessels in the most vascularized areas of the removed tumor can serve as a prognostic indicator. According to the results of clinical studies, in all patients (ie 100%) with the number of microvessels more than 100 at 200 fields of view of the light microscope, a relapse of the disease was observed, in comparison with 5% of patients where the density of microvessels was 33 or less.
As a result, research professor at the National Taiwan University - H.Changa, substances extracted from Enoki on cancersWas found a substance that blocks the growth of tumor blood system - a complex of protein and carbohydrate, glycoprotein FVE (from words Flammulina Velutipes - Extract). As a result, the impact on the body is a substance capable of inhibiting angiogenesis, blood oxygen without killed tumor cells and tumor growth occurs.
Prevention of cancer Maitake mushrooms, Enoki, agarika
This glycoprotein is selected such as the mushrooms meytake, Enoki, agarika he successfully inhibits tumor angiogenesis and induces apoptosis (programmed death) of tumor cells. meytake, Is also effective in the treatment of benign tumors (adenomas, fibroadenomas, polyps, fibroids, cysts, pappilom etc.)
On the issue tumor angiogenesis, you can always seek the advice of professionals of our center
В Kiev Center for Fungotherapy, Bioregulation and Ayurveda qualified doctors of alternative medicine are receiving. Cost of consultation 300 UAH. You can look at medical histories and treatment results on this link.
You can make an appointment by phone: (097) 231-74-44, (050) 331-74-44, (063) 187-78-78, +38 (098) 583-85-85 (Viber), +38 (093) 688-25- 88 (WhatsApp, Telegram) Email:This email address is being protected from spambots. You need JavaScript enabled to view it.